The Montana Highway Patrol reports the crash, which is believed to have been a head-on, happened just before 3 p.m. near Ravalli.
Brothers Benjamin Verde, 4, Eric Verde, 7, and Isaac Verde, 2, all Neosho residents, were pronounced dead at the scene, the patrol said.
The vehicle was westbound on Missouri Highway 86, about 30 miles southeast from Joplin, when the vehicle was struck by an eastbound tractor-trailer at 6:40 p.m.
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The mother and four others injured were taken to a Joplin hospital in ambulances, while a sixth person was flown to the hospital.
The cause of the crash is under investigation but MHP says it does not appear that speed was a factor.
MHP reports that the 65-year-old Polson woman, who was driving a Subaru Legacy, was northbound when she crossed the center line and collided with a Toyota FJ Cruiser carrying two occupants. It was the second-deadliest crash in Newton County in 2017, according to Deems. They were driving east in the direction of Fairview, where they reside.
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Five people in the third vehicle were taken to the hospital with injuries ranging from moderate to serious. Their ages and conditions were not available.
Two-year-old Isaac Verde was in a vehicle seat at the time of the crash, and Eric, 7, was wearing a seat belt, according to Lueckenhoff.
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