The Bucs (5-11), just two days after second-year head coach Dirk Koetter learned he would be retained for the 2018 season, broke a five-game losing streak and Winston (28 of 51 for 363 yards) gained a measure of redemption after throwing three critical interceptions earlier in the game.
Winston led a pair of 75-yard scoring drives in the opening half, but was also intercepted twice before halftime.
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New Orleans, which won its first NFC South title since 2011, did not blink, though.
He converted a fourth-and-10 from his own 5 yard line with a 12-yard completion to Cameron Brate and threw 9 yards to Mike Evans on third-and-1 to keep the drive going at the Tampa Bay 35. Isaiah Johnson recovered it and returned it for a 7-yard touchdown.
Godwin has seven receptions for 111 yards.
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Kamara topped 1,500 yards in impressive fashion, hauling a 40-yard pass from Drew Brees.
The Saints scored on the longest kickoff return in club history in the first quarter and took a 14-7 lead late in the period, but found itself in a bit of a struggle with Tampa Bay in the third quarter while nursing a 17-13 lead.
The Saints failed on an attempted fake field goal when kicker Wil Lutz was tackled one yard short of the first down.
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