Pakistan won the toss and elected to bat against New Zealand in the second one-day cricket global at Saxton Oval on Tuesday.
Pakistan captain Sarfraz Ahmed chose to bowl in the first match at the Basin Reserve and New Zealand went on to score 315-7 and to cruise to victory in a rain-affected match in which Pakistan lost two wickets in their first over.
When they were able to return to the field their new target under the Duckworth Lewis scoring system had been changed to 151 runs off 25 overs.
But while they got Colin Munro (0) early and Shadab took a great catch to remove Kane Williamson (19), Pakistan had no answers after the break as Guptill quickly took the game - and potentially the five-match series - away from them.
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Veteran allrounder Mohammad Hafeez (60 from 71) offered some much-needed resistance in the middle of the order before Hasan Ali (51 from 31) and Shadab Khan (52 from 68) combined for a blistering 70-run partnership as Pakistan raced through to 246 - an under par total but one they would have backed themselves to defend.
Imam-ul-Haq, in for the injured Fakhar Zaman, was out for two in the fourth over and Azhar Ali followed five balls later for six.
Guptill finished on 86 off 71 balls, which included five boundaries and five sixes, while Taylor remained undefeated on 45 off 43 deliveries, which included four boundaries.
The game was evenly poised when Guptill and Taylor ran for shelter in the 14th over but the experienced pair made a mockery of the run chase, with Guptill reaching his 33rd half century in a game-high 87 from 72 while Taylor chipped in with 44. Speaking to the media after the loss, Shadab Khan expressed his disappointment.
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Mohammad Hafeez top scored with 60, while Shadab Khan and Hasan Ali scored half centuires late in the innings.
Earlier the Pakistani's started slowly before getting through to 246 for 9 in their 50 overs.
Tim Southee (2-57) and Trent Boult (1-54) both claimed early wickets to give the bowling side the upper hand.
De Grandhomme missed the limited overs series against West Indies, and the first two ODIs against Pakistan, due to the death of his father in Zimbabwe.
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Faheem Ashraf and Sarfraz Ahmed were in and out in a jiffy as Pakistan slipped further. Tim Southee got the wicket in nearly identical fashion to the first ODI, Azhar falling over to off stump and missing a straight one that thudded into his pads.