Male contraceptive pill reports successful results from Phase 1 clinical trials

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The pill contains the activities of male hormone testosterone and also a female hormone progestin.

"These promising results are unprecedented in the development of a prototype male pill", said Dr. Stephanie Page, senior researcher and University of Washington professor in a statement.

More importantly, there were no major side-effects.

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"Despite having low levels of circulating testosterone, very few subjects reported symptoms consistent with testosterone deficiency or excess". One hundred men were randomized to receive daily oral placebo or DMAU with food in one of three dose groups (100, 200, and 400 mg) and one of two formulations (castor oil/benzyl benzoate [C] or powder in capsule [P]); 83 participants completed the study.

The idea of contraceptive pills for men has been floating about for some time now.

Study participants experienced slight decreases in HDL "good" cholesterol and slight weight gain, but these were not a risk for them.

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"DMAU is a major step forward in the development of a once-daily "male pill". Also, because they clear the body relatively quickly, men would have had to take the pills twice a day.

The results of the study, carried out with the help of Harbor-UCLA Medical Centre, were presented at ENDO 2018, the Endocrine Society's 100th annual meeting in Chicago.

There's a new contraceptive in town (well, not now, but possibly soon) and it aims to put the responsibility of safe sex square in the hands of men. It's 99 per cent effective when taken perfectly, Planned Parenthood wrote, but added that it's hard to do this. The team is now currently working on developing a second compound to block the other sperm-transporting protein with a goal of bringing a hormone-free, reversible male pill to the general public within ten years. It would work by blocking two proteins that cause sperms to be released, according to the lead researcher Dr Sab Ventura.

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The journey of creating such a pill has not been free of challenges that puzzled the scientists but they have managed to pass over them and to reach the point at which they were able to produce 100% working and safe contraceptive pills for men. Oral contraceptives are one of the medications most often used by Canadian women. To salvage the situation, men would also now have an option to take a drug that prevents pregnancy, thanks to a male contraceptive pill that is being developed towards that regard. The highest dose group displayed the most effective results showing "marked suppression" of testosterone levels and specific hormones related to sperm production.

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