AFP sought a response from the Egyptian foreign ministry but it was not immediately available.
Four others were also injured in the explosion in Alexandria, which located 200 km north of the capital Cairo.
The ministry said the bombing had targeted the convoy of Alexandria's security chief, General Mostafa al-Nemr.
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Two policemen were killed in a auto bomb attack Saturday targeting the security chief of Egypt's Alexandria, officials said, two days before the start of the country's presidential election.
State news agency MENA quoted al-Nemr as saying that two people, a policeman and a driver, were killed in the blast.
Pictures of the scene of the attack soon emerged on social media, showing the burnt-out remains of a auto surrounded by clouds of smoke.
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Local TV showed General al-Nimr inspecting the scene of the blast following the attack. His only challenger is a little-known candidate who supports him.
Sisi stormed to victory in a 2014 poll, a year after leading the military in ousting Egypt's first freely elected leader, the Islamist Mohamed Morsi. "The use of these kinds of explosive devices are common for terrorist elements unable to carry out any armed attack because the security forces have reduced their armed capacity in the raids on their hideouts and other operations in recent years".
IS bombed a hotel in Sinai in 2015 during a parliamentary election, killing seven people including two judges overseeing the vote.
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It has not yet been confirmed if the explosion is terror related, however Egyptian regime troops have been waging an offensive against an Islamic State-affiliated insurgency in the northern Sinai since February.