Argentina are not among the favourites, but with Messi there is always a chance and Sampaoli is well aware of that.
The 30-year-old missed the Albiceleste's 2-0 victory over Italy in last weekend's friendly at the Etihad Stadium in Manchester on Friday night, but was expected to feature against La Roja in Madrid.
Sampaoli insisted he was not gambling over his captain's fitness by fielding Messi against Spain.
"If there was any risk [of injury or aggravating the problem by playing], Leo would have said". The eve of the match against Italy he indicated that he was not in a state to play.
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It had previously appeared Messi would play in the game, with both he and manager Jorge Sampaoli confirming as much after the Italy win.
"I trained normallySunday, I feel good and I hope to play". Near misses in recent years have hurt and striker Sergio Aguero has said that it would be a failure if this great generation of players does not go on to lift a trophy together, thoughts echoed by many of his team-mates. "We are in a position where he is untouchable".
"Leo, you have to listen to him, create situations that will be optimal for him and from there build a team in relation to that". Dybala has to be pleased as he might participate in this summer's World Cup with Argentina after all.
Spain drew 1-1 with Germany in Dusseldorf on Friday, extending their unbeaten record under Julen Lopetegui to 17 matches. Moving from the right, when we cut inside, the whole pitch is in front of us.
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"It's more hard for us to play there, I don't often go out to the left".
Speaking ahead of Brazil's game against Germany, he said: "I think that Coutinho is a player who is on the same level as Ney, he has a massive influence on our game and in his teams".
Argentina face Spain in Madrid tonight. In the last friendly he told us so.
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He will also be free to play in the Indian Premier League for his franchise the Delhi Daredevils, starting 7 April. Shami is at the centre of controversy following a series of accusations made by his wife Hasin Jahan .