To general surprise, Zidane chose to take off Ronaldo after 64 minutes and replace him with Karim Benzema.
Despite Atleti enjoying a better season than Real domestically, however, Simeone insists that no side on the planet can match the quality in the European champions' ranks, including champions-elect Barcelona.
Ronaldo had earlier volleyed home the opening goal, and it was no surprise to see the forward score as he is in such red-hot form.
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The Portuguese did not appear to be carrying an injury, which made his removal even more of a surprise.
Simeone believes that Real Madrid's squad is the best in the world.
Atletico Madrid were behind for less than five minutes before Griezmann levelled.
Griezmann equalised for the visitors four minutes later after poking the ball into the net from inside the box, 1-1. A win for Atletico would distance them from Real by seven points, while Real can climb to within a point of their Madrid rivals with a win.
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France global Griezmann, 27, has now scored on each of his last three league visits to the Bernabeu and has 18 goals in his last 20 games in all competitions.
The Atletico star is clearly a fan of the video game Fortnite and has already given us a few celebrations inspired by the game.
Keylor Navas has reaffirmed his commitment to Real Madrid amid ongoing rumours of a change in the number one shirt at the Santiago Bernabeu.
Atleti remain sandwiched between leaders Barcelona and third-placed Madrid in LaLiga, four points better off than their neighbours. Los Blancos hold a 3-0 lead from the first leg in Turin and will be hot favourites to progress.
Crude oil prices dip slightly
Brent crude futures fell $1.23 on the day to $66.89 a barrel by 0918 GMT, bringing losses for the week so far to almost 5 percent. In New York, US light prices were down by $0.47 at $63.04 per barrel in mid-day trading.
Atletico have exclusively completed above their extra illustrious neighbors as soon as within the final 22 years, but heading into this weekend's sport they maintain a 4 level benefit over Zine dine Zidane's males.