'A short bang - there was a controlled explosion of the detonator away from the bomb, ' the police said.
Several government ministries, the German Intelligence Service, a courthouse and the Museum for Contemporary Art fall within the zone and were closed.
The 1,100lb bomb was believed to have been dropped by the British.
Police finally gave the all-clear at around 1:30pm after experts successfully disabled the bomb.
National Football League 2018 schedule: Super Bowl winners Philadelphia to face Jaguars at Wembley
The Texans have played in Mexico City, and Seattle does have an worldwide game, playing the Bills in Toronto in 2012. The league has also announced new start times for prime time games in the upcoming season.
Earlier, an 800 metre exclusion zone has been placed around the site of the bomb.
Police, who issued the warning on Wednesday, have asked residents to stay with family or friends or head to one of two emergency shelters set up at nearby schools.
The discovery had caused widescale disruption to the German capital.
More than seven decades after the end of World War II, Germany "still discovers more than 2,000 tonnes of live bombs and munitions every year", says Reuters.
Procter & Gamble pays €3.4B for Merck KGaA consumer health unit
Teva said the terms of the agreement to terminate the JV with P&G would not be disclosed and that the dissolution was amicable. Merck put the consumer health unit on the market a year ago in order to focus its efforts on prescription drugs.
More than 363 bombing raids were carried out on Berlin during the Second World War.
A bomb defusing team pose next to a 500-kilogram World War II bomb near the main train station in Berlin, Germany, April 20, 2018 in this handout photo posted by the Berlin Police on Twitter.
The British bomb has been removed, the main railway station has reopened and traffic is getting back to normal.
Nokia 8 Sirocco, Nokia 7 Plus Launched in India; Know Price, Specs
A 10% cashback is been given by ICICI Bank on usage of their credit and debit cards for payment procedure on Flipkart . Display: 5.5-inch (2560×1440 pixels) pOLED display, sculpted Corning Gorilla Glass 5 protection, 700 nits brightness.
The central station falls just inside the evacuation area, according to the BerlinerMorgenpost, and is a major stop for long-distance trains.