One village was extremely affected by running lava causing deaths and injuries.
"We are evacuating and rescuing people and have reports of 20 wounded, six dead and disappeared", said Cabanas.
Seven people have been killed and 20 hurt after a volcano near Guatemala City exploded in a fiery display of ash and lava.
A man cleans ashes from the Volcan de Fuego off his vehicle in Antigua Guatemala, Sacatepequez department, southwest of Guatemala City on Sun., June 3, 2018. "There are injured, burned and dead people", Sergio Cabanas, the general secretary of Guatemala's Conred disaster agency, said on radio.
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One video published by news outlet Telediario, purportedly taken in the El Rodeo village, showed three bodies strewn atop the remnants of the flow as rescuers arrived to attend to an elderly man caked from head to toe in ash and mud.
Firefighters said late Sunday that they had seen some people who were trapped in the area, but roads leading there were cut by pyroclastic flows and they had been unable to reach them.
Three bodies lay partially buried in ash-colored debris from the volcano, which lies about 27 miles (44 kilometers) from Guatemala City.
The eruption forced the Guatemala City's La Aurora worldwide airport to shut down its only runway.
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The conical Volcan de Fuego reaches an altitude of 12,346 feet above sea level at its peak. Streets and houses were covered in the colonial town of Antigua, a popular tourist destination.
The Guatemalan military said it was providing assistance including clearing volcanic ash from the airport's runway.
Photos from the scene showed massive plumes of black smoke in the air. "Where we saw the lava fall, we ran to a hillside" to escape, she added. "That could cause more mud flows and nearby rivers to burst their banks", said Eddy Sanchez, director of Guatemala's seismological, volcanic and meteorological institute.
Mario Cruz, a spokesman for the volunteer firefighter corps, said 3,100 people had evacuated the area so far.
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Officials have advised citizens to wear masks due to the falling ash.