"Initial reports show that approximately 20 people had sustained injuries ranging from minor to critical", said Russel Meiring, a spokesperson for ER24, a private emergency medical service, according to South Africa's Independent Online.
The 1954-built plane was soon to be flown to the Aviodrome air museum, near the central Dutch city of Lelystad, via Egypt, Croatia and Austria.
Images showed a burning aircraft marked "Martin's Air Charter".
Eyewitnesses described seeing the plane attempt to veer toward Wonderboom airport, then hearing an explosion.
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"There is smoke all over and paramedics are on the scene", eNCA news quoted a local police spokesman as saying.
He said the pilot was in a critical condition following the crash.
"We are unsure as yet of how the incident occurred".
"All we know is shortly after take-off the plane experienced trouble and crashed".
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Best Care ambulance services' Xander Loubser said reports indicated that the charter plane was carrying passengers on an worldwide flight.
South African Civil Aviation Authority spokesman Kabelo Ledwaba said its investigators were at the scene and would issue a statement.
"Paramedics are treating the patients and will thereafter transport them to nearby hospital for further treatment‚" Meiring said.
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Pompeo dismissed the stinging North Korean commentary and insisted that he made progress during his talks Friday and Saturday. Speaking privately, United States officials suggested the North Korean statement was a negotiating tactic.