Earlier, the West Indies were in trouble right from the start after skipper Jason Holder chose to bat.
The home side, led by a brisk half-century from the in-form Rohit Sharma and an unbeaten knock of 33 from captain Virat Kohli, motored to 105 for one in 14.5 overs, to wrap up the contest even before the scheduled break.
It was the West Indies' lowest total in a one-day worldwide against India, and their 10th lowest against any country. The other change saw West Indies beef up their fast bowling at the expense of a batsman - India amassed 377 in the fourth ODI - with Oshane Thomas replacing Chandrapaul Hemraj.
West Indies' T20 skipper Carlos Brathwaite Thursday sweated it out at the Eden Gardens, a ground where his four successive sixes in a World T20 final made him a household name.
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Ace India pacer Bhuvneshwar Kumar is just 2 wickets away from his 100 wickets in ODIs.
The big news in the batsmen's table was that of Windies batsmen Shai Hope and Shimron Hetmyer catapulting to No. 25 (up 22 spots) and No.26 (up 31 spots) respectively.
"To get runs as captain always gives me confidence". Rohit slammed five boundaries and four sixes in his 56-ball innings while Kohli played 29 balls and hammered six boundaries.
The two sides now head to Kolkata on Sunday for the first of three T20 internationals.
Fall of wkts: 1-1, 2-2, 3-36, 4-53, 5-57, 6-66, 7-87, 8-94, 9-103.
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Apart from Jadeja, Jasprit Bumrah and Khaleel Ahmed chipped in with two wickets each to derail the Windies innings.
The wickets of Keemo Paul (5), Kemar Roach (5) and Oshane Thomas for a duck followed soon after, as the Windies folded meekly.
RESULT: India won by nine wickets to win five-match 3-1.
MAN-OF-THE-SERIES: Virat Kohli.
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